The Miranda House Chemistry Department was established in 1960. It currently has three modern and well-equipped laboratories, two instrumentation laboratories and facilities of a modern computer laboratory.

Since Chemistry as a subject is central to the study of both physical and biological sciences, it offers a lot of scope to graduates in the discipline. While pursuing the Chemistry Honours course at Miranda House, many students are selected for summer training at the IITs and the Indian Institute of Science, Bangalore. A large number of Miranda House Chemistry graduates are pursuing post-graduate courses at the IITs and the IISc, Bangalore and some are also doing Ph.D. at top-ranking universities in the US, UK and Europe. Many Chemistry alumnae are engaged in research work at reputed pharmaceutical companies and research laboratories in India and abroad. The disciplined and analytical outlook acquired during the study of Chemistry helps graduates to excel in diverse fields such as Computer Programming, Ecology and Environment, Chartered Accountancy, Mass Communications, Management, Law and the Civil Services.